The Leducq Foundation has awarded a $9M grant to support an international research network focused on cerebral amyloid angiopathy.
The 5-year project is called Translational Framework For Innovation in Cerebral amyloid angiopathy, or TRAFFIC. It will be co-led by Antreas Charidimou, MD, PhD, of Boston University and Marcel Verbeek, PhD, MSc, of Radboud University Medical Center in the Netherlands.
Cerebral amyloid angiopathy is characterized by amyloid-beta buildup in the walls of brain blood vessels. Boston University said the condition is associated with brain bleeds, cognitive impairment, and dementia, including Alzheimer’s disease.
TRAFFIC will combine advanced brain imaging with molecular biomarkers and experimental models. The research team will study brain scans, body fluids, tissues, and clinical data from patients worldwide.
A central goal is earlier and more accurate CAA detection. The network will also investigate how the disease develops, progresses, and damages brain blood vessels, including CAA-related inflammation and amyloid-related imaging abnormalities.
“CAA is among the most common pathologies affecting the aging brain,” Charidimou said in Boston University’s announcement.
Network members listed by the Leducq Foundation include Matthew Schrag of Vanderbilt University Medical Center, Steven Greenberg of Harvard Medical School, Mar Hernandez Guillamon of Vall d’Hebron Research Institute, Stephanie Schreiber of Otto von Guericke University Magdeburg, and William Van Nostrand of the University of Rhode Island.
Training is also part of the initiative. Boston University said the network will provide mentorship, funding, and hands-on opportunities for early-career CAA researchers across participating laboratories.
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