NCCN adds AI-based mammogram analysis to breast cancer risk guidance

The National Comprehensive Cancer Network has updated its 2026 breast cancer screening and diagnosis guidelines to include AI-based mammogram analysis for 5-year breast cancer risk assessment, according to Clairity.

A 5-year breast cancer risk threshold of 1.7% or higher, informed by AI-based mammogram analysis, is now included as a criterion for identifying women at increased risk. The update also links risk assessment to clinical actions such as supplemental imaging and risk-reduction strategies.

The guideline update calls for periodic reassessment over time and expands identification of increased-risk individuals starting at age 35, the company said.

Clairity said its Clairity Breast model is cleared by the U.S. Food and Drug Administration for predicting 5-year breast cancer risk using AI-based mammography analysis. The company said it is currently the only such model available for commercial use.

The NCCN update targets a gap in current risk assessment based mainly on age, family history, breast density, and smoking history, according to the announcement. Clairity said image-based AI analysis may help identify women who do not meet traditional high-risk criteria.

The 2026 NCCN Breast Cancer Screening and Diagnosis Guidelines are published by the National Comprehensive Cancer Network, a nonprofit alliance of cancer centers that develops clinical practice guidelines in oncology.